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- Title
Deregulation of immunoglobulin gene transcription in the Hodgkin-Reed Sternberg cell line L1236.
- Authors
Re, Daniel; Staratschek-Jox, Andrea; Holtick, Udo; Diehl, Volker; Wolf, Jurgen
- Abstract
Focuses on experiments which provided functional evidence that crippling mutations in Hodgkin's disease which prevent immunoglobulin gene (Ig) expression can be located outside the coding regions of Ig genes. Definition of Hodgkin-Reed Sternberg cells; Interaction of B-cell specific transcription factors; Introduction of point mutations in the octamer motif.
- Subjects
IMMUNOGLOBULIN genes; HODGKIN'S disease; B cells
- Publication
British Journal of Haematology, 2001, Vol 115, Issue 2, p326
- ISSN
0007-1048
- Publication type
Article
- DOI
10.1046/j.1365-2141.2001.03086.x