We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Microwave‐Assisted Cross‐Coupling of Nitroarenes with Aryl Boronic Acids.
- Authors
Patel, Monak; Bhavyesh, Desai; Kumar, Nitish; Bhukya, Hussain; Dholakiya, Bharatkumar Z.; Naveen, Togati
- Abstract
A molybdenum‐catalyzed approach for intermolecular C−N coupling that produces aryl‐ and heteroaryl amines has been developed under microwave irradiation. The formation of C−N bonds with boronic acids and nitroaromatics using readily available catalysts remains a challenge. The method we developed employs a combination of readily available sodium molybdate dihydrate as a catalyst and tri‐n‐butyl phosphine as an inexpensive reductant to achieve reductive intermolecular coupling of nitroarenes with boronic acids. This approach has shown its versatility in facilitating the formation of Csp2−N bonds from aryl‐boronic acids as well as Csp3−N bonds from alkyl‐boronic acids. In addition, this reaction shows stereospecificity when Csp3−N bonds are formed. An array of boronic acids underwent C−N coupling with nitro arene providing the desired products in good yields
- Subjects
BORONIC acids; NITROAROMATIC compounds; SODIUM molybdate; STEREOSPECIFICITY; AMINES
- Publication
Asian Journal of Organic Chemistry, 2024, Vol 13, Issue 6, p1
- ISSN
2193-5807
- Publication type
Article
- DOI
10.1002/ajoc.202400064