We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Hexamethyldisilazane‐Mediated Synthesis of N‐Formamides, Benzimidazoles and Quinazolinones Using N,N‐Dimethylformamide as a C1 Source.
- Authors
Lin, Wei‐Han; Liang, Chien‐Fu
- Abstract
This paper presents a amidinyl transfer reagent for the synthesis of nitrogen‐containing compounds, wherein N,N‐dimethylformamide is used as the C1 source to react with hexamethyldisilazane, generating the N,N‐dimethylformimidamide intermediate. This intermediate is then reacted with amines to induce amidinyl transfer. This protocol can be applied for the synthesis of N‐formamide, benzimidazole and quinazolinone, for which amine derivatives used as substrates under optimized conditions. The advantages of this method are its operational simplicity, high efficiency, structural diversity in products with favorable yields, and applicability in gram‐scale operations.
- Subjects
QUINAZOLINONES; BENZIMIDAZOLES; DIMETHYLFORMAMIDE; AMINE derivatives; FORMAMIDINES; NITROGEN compounds; AMINES
- Publication
Asian Journal of Organic Chemistry, 2024, Vol 13, Issue 3, p1
- ISSN
2193-5807
- Publication type
Article
- DOI
10.1002/ajoc.202300603