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- Title
A General and Practical Synthesis of N-Aryl-3-[4-(imidazol-4-yl)-1,2,3-triazol-1-yl]benzamide Anti-Inflammatory Cytokine Inhibitors.
- Authors
Frutos, Rogelio P.; Rodriguez, Sonia; Patel, Nitinchandra D.; Reeves, Diana; Tampone, Thomas; SENanayake, Chris H.
- Abstract
A practical, safe, and efficient synthesis of anti-inflammatory cytokine inhibitors was developed and implemented for a number of analogues. A key aspect of the process is an efficient, one-pot, tandem copper-catalyzed azidonation and Huisgen 1,3-dipolar cycloaddition using silyl protected alkynes.
- Subjects
BENZAMIDE; PHYSIOLOGICAL effects of cytokines; HYDROCARBONS spectra; ALKYNES; RING formation (Chemistry); INFLAMMATION
- Publication
Asian Journal of Organic Chemistry, 2014, Vol 3, Issue 7, p769
- ISSN
2193-5807
- Publication type
Article
- DOI
10.1002/ajoc.201400002