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- Title
Antioxidant Activity and Oxidative Injury Protection for PC12 of Three Extracts from Cordyceps militaris Fruiting Bodies in vitro.
- Authors
Du Xiu-ju; Zhang Xiu-sheng; Zhang Jing-song; Jia Wei; Liu Yah-fang; Yang Yan; Tang Qing-jiu; Zhou Shuai
- Abstract
Cordyceps militaris fruiting bodies were extracted by using the method of systematic solvent extraction, and three different extracts were prepared named chloroform extract, acetic ether extract and ethanol extract, respectively. In vitro, the antioxidant activities of different extracts were investigated by using chemiluminescence measurements, and the activities of oxidative injury protection were assessed by using PC12 oxidative injury model induced with H2O2. The superoxide free radical (Due to image rights restrictions, multiple line equation(s) cannot be graphically displayed.) system and H2O2 system assays showed that the acetic ether extract had notable antioxidant activity, their scavenging rate for both H2O2 and Due to image rights restrictions, multiple line equation(s) cannot be graphically displayed. were highest among the three extracts, whose IC50 were 88.5 µg/ mL and 190 µg/mL, respectively. Moreover, the oxidative injury protection for PC12 assay showed that the acetic ether extract had significant rehabilitation effect in comparison with chloroform extract and ethanol extract, and it rehabilitated PC12 cell treated with H2O2 in a dose-dependent manner. Therefore, it was concluded that the acetic ether extract was the principal extract of both antioxidant and the activity of oxidative injury rehabilitation among three extracts from C. militaris fruiting bodies.
- Subjects
ANTIOXIDANTS; OXIDATIVE stress; CORDYCEPS; YEAST extract; SOLVENT extraction; CHEMILUMINESCENCE; FREE radicals
- Publication
Natural Product Research & Development, 2011, Vol 23, Issue 5, p905
- ISSN
1001-6880
- Publication type
Article