We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Prenatal Exposure to Bisphenols and Phthalates and Postpartum Depression: The Role of Neurosteroid Hormone Disruption.
- Authors
Jacobson, Melanie H.; Stein, Cheryl R.; Mengling Liu; Ackerman, Marra G.; Blakemore, Jennifer K.; Long, Sara E.; Pinna, Graziano; Romay-Tallon, Raquel; Kannan, Kurunthachalam; Hongkai Zhu; Trasande, Leonardo; Liu, Mengling; Zhu, Hongkai
- Abstract
<bold>Context: </bold>Postpartum depression (PPD) is a serious psychiatric disorder. While causes remain poorly understood, perinatal sex hormone fluctuations are an important factor, and allopregnanolone in particular has emerged as a key determinant. Although synthetic environmental chemicals such as bisphenols and phthalates are known to affect sex hormones, no studies have measured allopregnanolone and the consequences of these hormonal changes on PPD have not been interrogated.<bold>Objective: </bold>To investigate associations of repeated measures of urinary bisphenols and phthalates in early and midpregnancy with serum pregnenolone, progesterone, allopregnanolone, and pregnanolone concentrations in midpregnancy and PPD symptoms at 4 months postpartum.<bold>Methods: </bold>Prospective cohort study of 139 pregnant women recruited between 2016 and 2018. Bisphenols and phthalates were measured in early and midpregnancy urine samples. Serum sex steroid hormone concentrations were measured in midpregnancy. PPD was assessed at 4 months postpartum using the Edinburgh Postnatal Depression Scale (EPDS). Multiple informant models were fit using generalized estimating equations. Serum levels of allopregnanolone, progesterone, pregnanolone, and pregnenolone were examined as log-transformed continuous variables. PPD symptoms were examined as continuous EPDS scores and dichotomously with scores ≥10 defined as PPD.<bold>Results: </bold>Di-n-octyl phthalate (DnOP) and diisononyl phthalate (DiNP) metabolites were associated with reduced progesterone concentrations. Log-unit increases in ∑DnOP and ∑DiNP predicted 8.1% (95% CI -15.2%, -0.4%) and 7.7% (95% CI -13.3%, -1.7%) lower progesterone, respectively. ∑DnOP was associated with increased odds of PPD (odds ratio 1.48; 95% CI 1.04, 2.11).<bold>Conclusion: </bold>Endocrine disrupting chemicals may influence hormonal shifts during pregnancy as well as contribute to PPD.
- Subjects
BISPHENOL A; POSTPARTUM depression; BISPHENOLS; PHTHALATE esters; HORMONES; PASSIVE smoking; PSYCHOLOGY of puerperium; BENZENE; MATERNAL exposure; RESEARCH; PHENOLS; POLLUTANTS; PROGESTERONE; STEROIDS; DURATION of pregnancy; RESEARCH methodology; MEDICAL cooperation; EVALUATION research; PSYCHOLOGICAL tests; COMPARATIVE studies; PUERPERIUM; RESEARCH funding; CARBOCYCLIC acids; LONGITUDINAL method; EDINBURGH Postnatal Depression Scale
- Publication
Journal of Clinical Endocrinology & Metabolism, 2021, Vol 106, Issue 7, p1887
- ISSN
0021-972X
- Publication type
journal article
- DOI
10.1210/clinem/dgab199