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- Title
Comparative two time-point proteome analysis of the plasma from preterm infants with and without bronchopulmonary dysplasia.
- Authors
Zasada, Magdalena; Suski, Maciej; Bokiniec, Renata; Szwarc-Duma, Monika; Borszewska-Kornacka, Maria Katarzyna; Madej, Józef; Bujak-Giżycka, Beata; Madetko-Talowska, Anna; Revhaug, Cecilie; Baumbusch, Lars O.; Saugstad, Ola D.; Pietrzyk, Jacek Józef; Kwinta, Przemko
- Abstract
Background: In this study, we aimed to analyze differences in plasma protein abundances between infants with and without bronchopulmonary dysplasia (BPD), to add new insights into a better understanding of the pathogenesis of this disease. Methods: Cord and peripheral blood of neonates (≤ 30 weeks gestational age) was drawn at birth and at the 36th postmenstrual week (36 PMA), respectively. Blood samples were retrospectively subdivided into BPD(+) and BPD(−) groups, according to the development of BPD. Results: Children with BPD were characterized by decreased afamin, gelsolin and carboxypeptidase N subunit 2 levels in cord blood, and decreased galectin-3 binding protein and hemoglobin subunit gamma-1 levels, as well as an increased serotransferrin abundance in plasma at the 36 PMA. Conclusions: BPD development is associated with the plasma proteome changes in preterm infants, adding further evidence for the possible involvement of disturbances in vitamin E availability and impaired immunological processes in the progression of prematurity pulmonary complications. Moreover, it also points to the differences in proteins related to infection resistance and maintaining an adequate level of hematocrit in infants diagnosed with BPD.
- Subjects
BIOMARKERS; BLOOD proteins; BRONCHOPULMONARY dysplasia; CARRIER proteins; CHILDREN'S health; COMPARATIVE studies; CORD blood; GESTATIONAL age; HEMATOCRIT; HEMOGLOBINS; INFECTION; MICROFILAMENT proteins; PROTEOLYTIC enzymes; TRANSFERRIN; VITAMIN E; PROTEOMICS; DISEASE progression; CHILDREN
- Publication
Italian Journal of Pediatrics, 2019, Vol 45, Issue 1, pN.PAG
- ISSN
1720-8424
- Publication type
Article
- DOI
10.1186/s13052-019-0676-0