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- Title
Prosurvival Pathway Protects From Clostridioides difficile Toxin-Mediated Cell Death.
- Authors
Tornel, William; Sharma, Ishrya; Osmani, Hiba; Moonah, Shannon
- Abstract
There is an urgent need for new nonantibiotic-based treatment strategies for Clostridioides difficile infection. C. difficile toxin B (TcdB) is a virulent factor that is essential for causing disease. Here, we investigated whether a survival-signaling pathway could protect against TcdB. We found significant increase in caspase-3 apoptotic activity in intestinal epithelial cells of mice exposed to TcdB. Subsequently, activation of the MIF-CD74-Akt prosurvival signaling pathway blocked TcdB-induced caspase-3 activity and intestinal epithelial cell death. This brief report provides proof-of-concept that targeting prosurvival pathways may represent a unique antibiotic-independent strategy for protecting against C. difficile toxin-mediated cell death.
- Subjects
CLOSTRIDIOIDES difficile; CELL death; EPITHELIAL cells; CASPASES; CELLULAR signal transduction
- Publication
Journal of Infectious Diseases, 2024, Vol 229, Issue 5, p1519
- ISSN
0022-1899
- Publication type
Article
- DOI
10.1093/infdis/jiad481