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- Title
Humoral response after accelerated schedule of HBV vaccination in MS patients before anti-CD20 therapy.
- Authors
Maillart, Elisabeth; Todesco, Eve; Assoumou, Lambert; Beigneux, Ysoline; Lubetzki, Catherine; Papeix, Caroline; De Paz, Raphael; Dubessy, Anne-Laure; Djebara, Siham; Louapre, Céline; Pourcher, Valérie
- Abstract
This document is a letter published in the Journal of Neurology discussing the humoral response to an accelerated schedule of hepatitis B virus (HBV) vaccination in patients with multiple sclerosis (MS) before receiving anti-CD20 therapy. The study was conducted in France and aimed to evaluate the efficacy and safety of the accelerated vaccination schedule. The results showed that 58.8% of MS patients achieved seroconversion after the first three injections of the vaccine, which is lower than the reported seroconversion rate for a standard vaccination schedule. The study also highlighted the need for long-term monitoring of immune responses and education on the risks of HBV transmission in MS patients.
- Subjects
HEPATITIS B vaccines; HIV seroconversion; JOHN Cunningham virus; HUMORAL immunity; DISEASE risk factors
- Publication
Journal of Neurology, 2024, Vol 271, Issue 5, p2871
- ISSN
0340-5354
- Publication type
Article
- DOI
10.1007/s00415-023-12175-2