We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Development and persistence of posttraumatic stress disorder and the 5-HTTLPR polymorphism.
- Authors
Thakur, Geeta A.; Joober, Ridha; Brunet, Alain
- Abstract
Association between 5-HTTLPR polymorphism and development of acute and persistence of chronic posttraumatic stress disorder (PTSD) was prospectively investigated. DNA was extracted from 41 motor-vehicle accident victims evaluated for development and persistence of PTSD, 1 and 12 months posttrauma. At Time 1, a nonsignificant trend for higher acute PTSD rate in ll homozygotes (82%) was observed compared to those with ss and sl genotypes (50%). At Time 2, higher chronic PTSD rate was found in ll homozygotes (55%) compared to those with ss and sl genotypes (20%), with an odds ratio of 4.8 (95% CI = 1.09–21.22). Contrary to previous findings, these data are suggestive of a protective role for the s allele of 5-HTTLPR in chronic PTSD.
- Subjects
POST-traumatic stress disorder; TRAUMATIC neuroses; TRAGEDY (Trauma); PSYCHOLOGICAL stress; PSYCHOSOMATIC disorders; PATHOLOGICAL psychology; GENE frequency; GENETIC polymorphisms; DNA
- Publication
Journal of Traumatic Stress, 2009, Vol 22, Issue 3, p240
- ISSN
0894-9867
- Publication type
Article
- DOI
10.1002/jts.20405