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- Title
Highly Enantioselective Construction of Tricyclic Derivatives by the Desymmetrization of Cyclohexadienones.
- Authors
Martín ‐ Santos, Cecilia; Jarava ‐ Barrera, Carlos; del Pozo, Sandra; Parra, Alejandro; Díaz ‐ Tendero, Sergio; Mas ‐ Ballesté, Rubén; Cabrera, Silvia; Alemán, José
- Abstract
The asymmetric synthesis of tricyclic compounds by the desymmetrization of cyclohexadienones is presented. The reaction tolerated a large variety of substituents at different positions of the cyclohexadienone, and heterocyclic rings of different sizes were accessible. Density functional theory calculations showed that the reaction proceeds through an asynchronous [4+2] cycloaddition.
- Subjects
CYCLOHEXADIENONES; ENANTIOSELECTIVE catalysis; ASYMMETRIC synthesis; HETEROCYCLIC compound derivatives; RING formation (Chemistry); DENSITY functional theory
- Publication
Angewandte Chemie, 2014, Vol 126, Issue 31, p8323
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201402853