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- Title
Inhibition of Heme Uptake in Pseudomonas aeruginosa by its Hemophore (HasA<sub>p</sub>) Bound to Synthetic Metal Complexes.
- Authors
Shirataki, Chikako; Shoji, Osami; Terada, Mitsuyoshi; Ozaki, Shin ‐ ichi; Sugimoto, Hiroshi; Shiro, Yoshitsugu; Watanabe, Yoshihito
- Abstract
The heme acquisition system A protein secreted by Pseudomonas aeruginosa (HasAp) can capture several synthetic metal complexes other than heme. The crystal structures of HasAp harboring synthetic metal complexes revealed only small perturbation of the overall HasAp structure. An inhibitory effect upon heme acquisition by HasAp bearing synthetic metal complexes was examined by monitoring the growth of Pseudomonas aeruginosa PAO1. HasAp bound to iron-phthalocyanine inhibits heme acquisition in the presence of heme-bound HasAp as an iron source.
- Subjects
PSEUDOMONAS aeruginosa; HEME; QUANTUM perturbations; PATHOGENIC bacteria; HEMOPROTEINS; CRYSTAL structure
- Publication
Angewandte Chemie, 2014, Vol 126, Issue 11, p2906
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201307889