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- Title
K-ras Cancer Gene Mutations in Lung Tumors From Female Swiss (CD-1) Mice Exposed Transplacentally to 3′-Azido-3′-Deoxythymidine.
- Authors
Koujitani, Takatoshi; Ton, Tai-Vu T.; Lahousse, Stephanie A.; Hong, Hue-Hua L.; Wakamatsu, Nobuko; SiIIs, Robert C.
- Abstract
The article presents a study of transplacental carcinogenicity in a female Swiss mice showing the K-ras cancer gene mutations in lung tumors. It indicates that K-ras is detected by sequencing the polymerase chain reaction (PCR)- amplified DNA, separate from the formalin-fixed, paraffin embedded lung tumors. Researchers claim that the findings in female mice suggest that AZT, its metabolites, or the conditions associated with AZT exposure such as enhanced oxidative stress, contributed to the development of the lung tumors in exposed female mice. They also emphasize the importance of evaluating both the cellular and molecular endpoints in cancer studies.
- Subjects
PLACENTA; CARCINOGENICITY testing; CANCER; GENES; LUNG tumors; POLYMERASE chain reaction; FORMALDEHYDE; PARAFFIN wax; METABOLITES
- Publication
Environmental & Molecular Mutagenesis, 2008, Vol 49, Issue 9, p720
- ISSN
0893-6692
- Publication type
Article
- DOI
10.1002/em.20420