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- Title
Prenatal diagnosis of congenital cytomegalovirus infection: false-negative amniocentesis at 20 weeks' gestation.
- Authors
Catanzarite, Val; Dankner, Wayne M.; Catanzarite, V; Dankner, W M
- Abstract
Cytomegalovirus (CMV) is the most common cause of congenital infection. Recent studies show amniocentesis to be a 100 per cent sensitive and 100 per cent specific predictor of congenital infection, and recommend that it be offered in the at-risk pregnancy. However, these publications have focused on pregnancies at or beyond 22 weeks' gestation. Here, we report a case of maternal CMV hepatitis at 7-8 weeks' gestation, in which culture and polymerase chain reaction testing for CMV in amniotic fluid at 20 weeks' gestation were negative, but the infant had a positive CMV urine culture shortly after delivery. Implications for the prenatal diagnosis of CMV infection are discussed.
- Publication
Prenatal Diagnosis, 1993, Vol 13, Issue 11, p1021
- ISSN
0197-3851
- Publication type
journal article
- DOI
10.1002/pd.1970131103