We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Antiplasmodial activity of artecyclopentyl mether a new artemisinin derivative and its effect on pathogenesis in Plasmodium yoelii nigeriensis infected mice.
- Authors
Agarwal, Jyoti; Singh, Suriya; Chanda, Debabrata; Bawankule, Dnyaneshwar; Bhakuni, Rajendra; Pal, Anirban
- Abstract
In an effort to evaluate novel derivatives from artemisinin, possessing potential antimalarial activity, a new derivative artecyclopentyl mether (CPM-1) was derivatized and evaluated for its dose-dependent efficacy in Plasmodium yoelii nigeriensis infected mice. The survivability of mice at 7.5 mg/kg was >28 days with negligible parasitaemia and recovered anemia (66.16-72.62%). Artecyclopentyl mether was also found to modulate the pro- and anti-inflammatory cytokines (IFN-γ, 39.64-56.92%; TNF, 49.10-74.31%; IL-4, 11.53-43.22%; IL-10, 37.60-53.52%) favourably besides optimizing the oxidative stress to the infected subjects as evident by the nitric oxide (88.76-95.43%), lipid peroxidation (59.30-76.05%) and glycaemic data (62.70-76.66%). The results indicate the potentiality of the new derivative as an antimalarial against asexual stages of the parasite.
- Subjects
ARTEMISININ; LABORATORY mice; ANTIMALARIALS; OXIDATIVE stress; PEROXIDATION
- Publication
Parasitology Research, 2011, Vol 109, Issue 4, p1003
- ISSN
0932-0113
- Publication type
Article
- DOI
10.1007/s00436-011-2344-1