We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Diagnostic approach in hepatic lymphoma: radiological imaging findings and literature review.
- Authors
Ippolito, Davide; Porta, Marco; Maino, Cesare; Pecorelli, Anna; Ragusi, Maria; Giandola, Teresa; Querques, Giulia; Talei Franzesi, Cammillo; Sironi, Sandro
- Abstract
Purpose: Imaging manifestations of hepatic lymphoma, both primary (PHL) and secondary (SHL), are extremely variable and non-specific, but some features are useful diagnostic clues in an appropriate clinical setting. Through a PubMed search, we found several published reviews focused on PHL and SHL diagnosis. However, to the best of our knowledge, few of them encompass a comprehensive analysis of all the diagnostic tools and relative radiological findings. The aim of this review is to provide a description of the radiological features of both PHL and SHL, by critically analyzing the available literature. Materials and methods: An extensive review of published literature along with a description of personal case series of both PHL and SHL has been conducted. Results: SHL can be easily diagnosed with imaging techniques, as it is usually associated with node disease. On the contrary the diagnosis can be a challenge in PHL, often mimicking HCC or liver metastasis of adenocarcinoma. In this context, multiparametric MRI plays a fundamental role in the differential diagnosis. Both for PHL and SHL, liver involvement presents as solitary or multiple lesions or as diffuse infiltrative disease. Conclusion: PHL and SHL may be correctly characterized using different radiological techniques. Both CT and MRI have showed a good correlation with histology, as they permit to distinguish between lymphomatous tissue, and necrotic and fibrotic areas.
- Subjects
LITERATURE reviews; LYMPHOMAS; LIVER metastasis; DIFFERENTIAL diagnosis
- Publication
Journal of Cancer Research & Clinical Oncology, 2020, Vol 146, Issue 6, p1545
- ISSN
0171-5216
- Publication type
Article
- DOI
10.1007/s00432-020-03205-x