We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Intraocular metastases: differential diagnosis from uveal melanomas with high-resolution MRI using a surface coil.
- Authors
Lemke, Arne-Jörn; Hosten, Norbert; Wiegel, Thomas; Prinz, Robert D.; Richter, Miriam; Bechrakis, Nikolaos E.; Foerster, Paul I.; Felix, Roland; Lemke, A J; Hosten, N; Wiegel, T; Prinz, R D; Richter, M; Bechrakis, N E; Foerster, P I; Felix, R
- Abstract
Magnetic resonance imaging with dedicated surface coils plays a pivotal role in differential diagnosis and staging of intraocular tumors. The purpose of this study was to establish MRI criteria for the differential diagnosis of uveal melanomas and intraocular metastases. In a prospective study 44 eyes in 36 patients with intraocular metastases and 200 patients with uveal melanomas were investigated with MRI using a 1.5-T scanner and a 5-cm surface coil. Both quantitative and qualitative evaluation of the resulting images was performed. The MR signal intensities typically expected for metastases (slightly hyperintense on non-contrast T1-weighted images and hypointense on T2-weighted images compared to the vitreous body) were seen in only 23.1%. The typical melanoma signal of either moderate or strong hyperintensity on T1-weighted images and hypointensity on T2-weighted images was seen in 69.4% of the proven melanomas. Contrast enhancement was observed in both metastases and melanomas. Morphological differences between metastases and melanomas were detected in tumor size, shape, position, frequency of retinal detachment, and homogeneity of the tumor. Differentiation between intraocular metastases and uveal melanoma is limited by overlap of signal intensities. Some improvement is achieved with morphologic criteria.
- Subjects
MELANOMA; NEUROENDOCRINE tumors; METASTASIS; PATHOLOGY; MAGNETIC resonance imaging; MEDICAL imaging systems; MAGNETIC resonance imaging equipment; MELANOMA diagnosis; DIAGNOSTIC imaging equipment; COMPARATIVE studies; DIFFERENTIAL diagnosis; LONGITUDINAL method; RESEARCH methodology; MEDICAL cooperation; RESEARCH; UVEA; UVEA cancer; EVALUATION research
- Publication
European Radiology, 2001, Vol 11, Issue 12, p2593
- ISSN
0938-7994
- Publication type
journal article
- DOI
10.1007/s003300100936