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- Title
Drosophila small cytoplasmic 19S ribonucleoprotein is homologous to the rat multicatalytic proteinase.
- Authors
Falkenburg, Patricia-E.; Haass, Christian; Kloetzel, Peter-M.; Niedel, Barbara; Kopp, Friedrich; Kuehn, Lothar; Dahlmann, Burkhardt
- Abstract
All eukaryotic cells so far analysed contain 19S particles which share a cylinder-like shape and are composed of a set of proteins of relative molecular mass ranging typically from 19,000 to 36,000 (refs 1-10). Proposed functions have included synthetase activity11, transfer RNA processing12 or messenger RNA repression6, but their biological importance remains obscure. A multicatalytic proteinase (MCP) of similar size and shape has been isolated from mammalian tissues13-24. The apparent similarities of these high molecular weight complexes suggest a biochemical and functional homology between the small cytoplasmic 19S particle from Drosophila melanogaster (19S-scRNP) (ref. 7) and rat MCP (ref. 14). By means of electron microscopy, immunological techniques, RNA identification and proteinase activity assays, we were able to show that the two structurally similar complexes are immunologically related ribonucleoproteins (RNPs) with similar proteolytic activity.
- Publication
Nature, 1988, Vol 331, Issue 6152, p190
- ISSN
0028-0836
- Publication type
Article
- DOI
10.1038/331190a0