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- Title
Phenotypic and genotypic Helicobacter pylori clarithromycin resistance and therapeutic outcome: benefits and limits.
- Authors
De Francesco, Vincenzo; Zullo, Angelo; Ierardi, Enzo; Giorgio, Floriana; Perna, Federico; Hassan, Cesare; Morini, Sergio; Panella, Carmine; Vaira, Dino
- Abstract
Introduction: Primary clarithromycin resistance is increasing worldwide, and it has been regarded as the main factor reducing the efficacy of Helicobacter pylori therapy. However, the clinical consequence of either phenotypic or genotypic resistance still remains unclear. This study aimed to evaluate: (i) the concordance between phenotypic (culture) and genotypic (real-time PCR) tests in assessing primary clarithromycin resistance; and (ii) the role of both in therapeutic outcome.
- Subjects
HELICOBACTER pylori; DRUG resistance; PHENOTYPES; DRUG efficacy; PHARMACOLOGY; PYLORUS
- Publication
Journal of Antimicrobial Chemotherapy (JAC), 2010, Vol 65, Issue 2, p327
- ISSN
0305-7453
- Publication type
Article
- DOI
10.1093/jac/dkp445