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- Title
Effect of plaunotol in combination with clarithromycin against clarithromycin-resistant Helicobacter pylori in vitro and in vivo.
- Authors
Makoto Sasaki; Tsutomu Mizoshita; Takashi Mizushima; Harumi Inoue; Takeshi Kamiya; Hiromi Kataoka; Naotaka Ogaswara; Tsuneya Wada; Eiji Kubota; Yoshinori Mori; Takaya Shimura; Hirokazu Hirata; Kenji Ando; Yasuyuki Okamoto; Hirotaka Ohara; Haruhisa Nakao; Takashi Joh
- Abstract
Objectives Recently, there has been a decrease in the eradication rate of Helicobacter pylori due to the increase in antibiotic resistance of this bacterium. Plaunotol, a cytoprotective anti-ulcer agent, exhibits antibacterial activity against H. pylori. The purpose of the present study was to investigate the effect of plaunotol in combination with clarithromycin against clarithromycin-resistant H. pylori clinical isolates. Methods and results In the chequerboard titration method, the combination of plaunotol and clarithromycin showed a synergistic effect against 67% (10/15) clarithromycin-resistant strains and an additive effect against the other strains. No indifferent and antagonistic effects were observed against any of the strains tested. In a gastritis model of Mongolian gerbils infected with clarithromycin-resistant H. pylori, the plaunotol (40 mg/kg) and clarithromycin (66.6 mg/kg) combination exhibited synergistic effects; however, neither plaunotol nor clarithromycin alone showed bactericidal effects. Conclusions These results suggest that plaunotol may play a useful role in combination with anti-H. pylori drugs in the treatment of diseases associated with clarithromycin-resistant H. pylori.
- Subjects
HELICOBACTER; PYLORUS; HELICOBACTER pylori; GOAL (Psychology)
- Publication
Journal of Antimicrobial Chemotherapy (JAC), 2007, Vol 60, Issue 5, p1060
- ISSN
0305-7453
- Publication type
Article
- DOI
10.1093/jac/dkm329