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- Title
Comparison of analgesic effect of direct breastfeeding, oral 25% dextrose solution and placebo during 1 DPT vaccination in healthy term infants: A randomized, placebo controlled trial.
- Authors
Goswami, Gaurav; Upadhyay, Amit; Gupta, Navratan; Chaudhry, Rajesh; Chawla, Deepak; Sreenivas, V.
- Abstract
Objective: To compare analgesic effect of direct breast feeding, 25% dextrose solution and placebo as we give 1st intramuscular whole cell DPT injection to 6week - 3month old infants. Design: Randomized, placebo controlled trial. Setting: Immunization clinic of Department of Pediatrics, LLRM Medical College. Participants: Infants coming for their 1st DPT vaccination were randomized in to three groups of 40 each. Outcome measures: The primary outcome variable was the duration of cry after vaccination. Secondary outcome variables were Modified Facial Coding Score (MFCS) and latency of onset of cry. Results: 120 babies were equally enrolled in breast feed group, 25% dextrose fed group and distilled water fed group. Median (interquartile range) of duration of cry was significantly lower in breast fed (33.5 (17-54) seconds) and 25% dextrose fed babies (47.5 (31-67.5) seconds) as compared to babies given distilled water (80.5 (33.5-119.5) seconds) ( P<0.001). MFCS at 1 min and 3 min was significantly lower in direct breast fed and dextrose fed babies. Conclusions: Direct breastfeeding and 25% dextrose act as analgesic in young infants undergoing DPT vaccination in young infants less than 3 month of age.
- Subjects
ANALGESICS; BREASTFEEDING; PLACEBOS; DPT vaccines; IMMUNIZATION; VACCINATION
- Publication
Indian Pediatrics, 2013, Vol 50, Issue 7, p649
- ISSN
0019-6061
- Publication type
Article
- DOI
10.1007/s13312-013-0196-8