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- Title
Opinion: ?-Secretase: proteasome of the membrane?
- Authors
Kopan, Raphael; Ilagan, Ma. Xenia G.
- Abstract
γ-Secretase - a protease that cleaves within the membrane - was first recognized for its role in the production of amyloidogenic Aß peptides, but was subsequently found to mediate Notch signalling by releasing the Notch-receptor intracellular domain. Many other ?-secretase substrates have recently been identified, which indicates a broader biological function for this unusual protease. Emerging evidence implies that whereas some intracellular cleavage products of ?-secretase function as signalling molecules, others might simply be intermediates that are destined for degradation.
- Subjects
PROTEOLYTIC enzymes; HYDROLASES; PEPTIDES; BIOLOGICAL membranes; MOLECULES
- Publication
Nature Reviews Molecular Cell Biology, 2004, Vol 5, Issue 6, p499
- ISSN
1471-0072
- Publication type
Article
- DOI
10.1038/nrm1406