We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Effect of pattern scanning laser on macular thickness in diabetic retinopathy.
- Authors
Hamed, Nadine; Vander Woude, Logan; Roohipourmoallai, Ramak; Ohning, Collin; Regan, Kathleen A.; Iyer, Siva S.R.
- Abstract
Purpose: This study investigates the effect of pattern scanning laser (PASCAL) panretinal photocoagulation (PRP) on central macular thickness (CMT) and visual acuity (VA) in patients with proliferative diabetic retinopathy (PDR). Methods: This retrospective non-randomized comparative case series included 262 eyes (163 with macular edema) of 177 patients with PDR. Treatment was PRP alone (137), PRP + anti-vascular endothelial growth factor (VEGF) (69), PRP + focal laser (28), or all three (89). CMT and central macular volume 3 and 6 mm from fovea were analyzed before and 1, 3, and 6 months after PRP. Spot number was plotted against CMT, and linear regression analysis was performed. Results: For each treatment group and time point, there was a non-significant relationship between spot number and CMT. In eyes receiving all three treatment modalities, a significant negative relationship was found between spot number and 3-mm volume at 6 months (p = 0.04) and 6-mm volume at 1 month (p = 0.002) and 6 months (p = 0.011). There was no significant change in VA in any treatment group at the 6-month time point. Conclusion: PASCAL PRP ± focal laser or anti-VEGF was not associated with increased development of macular edema or change in VA. PASCAL PRP with focal laser and anti-VEGF may result in a decrease in macular edema.
- Subjects
SURGICAL complication risk factors; VASCULAR endothelial growth factor antagonists; RETINAL degeneration; DISEASE risk factors; EXPERIMENTAL design; ACQUISITION of data methodology; MEDICAL lasers; RETROSPECTIVE studies; REGRESSION analysis; RISK assessment; TREATMENT effectiveness; COMPARATIVE studies; PRE-tests &; post-tests; VISUAL acuity; CASE studies; MEDICAL records; DESCRIPTIVE statistics; DIABETIC retinopathy; CONTROL groups; OPHTHALMIC surgery; EVALUATION
- Publication
Therapeutic Advances in Ophthalmology, 2021, p1
- ISSN
2515-8414
- Publication type
Article
- DOI
10.1177/25158414211035860