We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Regulation of Uni-Strand and Dual-Strand piRNA Clusters in Germ and Somatic Tissues in Drosophila melanogaster under Control of rhino.
- Authors
Milyaeva, P. A.; Lavrenov, A. R.; Kuzmin, I. V.; Kim, A. I.; Nefedova, L. N.
- Abstract
Drosophila melanogaster is a common genetic object for research of RNA interference pathways and regulation of mobile elements. At present, taking part in control of retrotransposon expression, the system of piRNA interference is well studied in ovary tissues. It is strongly believed that, in D. melanogaster, the system of piRNA interference is used for retrotransposon suppression only in the gonads, and two distinct pathways of piRNA biogenesis exist. Both mechanisms use transcripts of piRNA clusters (accumulations of truncated and defective copies of mobile elements): from uni-strand clusters in the first case and from dual-strand clusters in the second case, transcribed from one or both DNA chains, respectively. It is well known that proper function of dual-strand clusters depends on the gene rhino, while uni-strand clusters are transcribed and then spliced independently of rhino. In this paper, we show that rhino participates in splicing of uni-strand cluster flamenco transcripts. Moreover, the system of piRNA interference is necessary for regulation of several retrotransposons not only in the gonads but also in other organs.
- Subjects
DROSOPHILA melanogaster; RNA interference; SMALL interfering RNA; RHINOCEROSES; MICROORGANISMS; DROSOPHILIDAE; RETROTRANSPOSONS; GONADS
- Publication
Russian Journal of Genetics, 2023, Vol 59, Issue 12, p1288
- ISSN
1022-7954
- Publication type
Article
- DOI
10.1134/S1022795423120050