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- Title
Predictive value of D-dimer in the clinical outcome of severe COVID19 patients: Are we giving it too much credit?
- Authors
Cidade, José P.; Coelho, Luís; Costa, Vasco; Morais, Rui; Moniz, Patrícia; Morais, Luís; Fidalgo, Pedro; Tralhão, António; Paulino, Carolina; Nora, David; Valerio, Bernardino; Mendes, Vítor; Tapadinhas, Camila; Póvoa, Pedro
- Abstract
Background: COVID-19 is a new form of acute respiratory failure leading to multiorgan failure and ICU admission. Gathered evidence suggests that a 3-fold rise in D-dimer concentrations may be linked to poor prognosis and higher mortality. Purpose: To describe D-dimer admission profile in severe ICU COVID19 patients and its predictive role in outcomes and mortality. Methods: Si ngle-center retrospective cohort study. All adult patients admitted to ICU with COVID19 were divided into 3 groups: (1) Lower-values group (D-dimer levels < 3-fold normal range value [NRV] [500ng/mL]), Intermediate-values group (D-dimer ≥3-fold and <10-fold NRV) and Higher-value group (≥10-fold NRV). Results: 118 patients (mean age 63 years, 73% males) were included (N = 73 Lower-values group, N = 31 Intermediate-values group; N = 11 Higher-values group). Mortality was not different between groups (p = 0.51). Kaplan-Meier survival curves revealed no differences (p = 0.52) between groups, nor it was verified even when gender, age, ICU length of stay, and SOFA score were considered as covariables. Conclusions: In severe COVID19 patients, the D-dimer profile does not retain a predictive value regarding patients' survivability and should not be used as a surrogate of disease severity.
- Subjects
FIBRIN fragment D; COVID-19; ADULT respiratory distress syndrome; TREATMENT effectiveness; MULTIPLE organ failure
- Publication
Clinical & Applied Thrombosis/Hemostasis, 2022, Vol 28, p1
- ISSN
1076-0296
- Publication type
Article
- DOI
10.1177/10760296221079612