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- Title
N-myc Oncogene RNA Expression in Neuroblastoma.
- Authors
Nisen, Perry D.; G.Waber, Pamela; Rich, Mark A.; Pierce, Sean; Garvin, James R.; Gilbert, Fred; Lanzkowsky, Philip
- Abstract
Tumor specimens from 33 patients with neuroblastoma were assayed for amplification of the N-myc oncogene and RNA expression to determine whether N-myc RNA expression levels correlated with N-myc gene amplification and clinical outcome. N-myc gene amplification was detected in one stage II tumor, one stage IV–S tumor, and seven stage III or IV tumors. In each case, N-myc RNA expression roughly paralleled N-myc gene amplification. However, enhanced N-myc RNA expression was not confined to tumors with N-myc gene amplification: all of the early (stage I and II) tumors, five stage IV-S tumors, and 12 advanced (stage III and IV) tumors had levels of N-myc RNA that were elevated up to 50-fold. While N-myc gene amplification correlated with prognosis, there was no such correlation with levels of N-myc RNA expression. The precise role of the N-myc gene in the pathogenesis of neuroblastoma remains unclear.
- Publication
JNCI: Journal of the National Cancer Institute, 1988, Vol 80, Issue 20, p1633
- ISSN
0027-8874
- Publication type
Article