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- Title
Is Altered Expression of Hepatic Insulin-Related Genes in Growth Hormone Receptor Knockout Mice Due to GH Resistance or a Difference in Biological Life Spans?
- Authors
Panici, Jacob A.; Wang, Feiya; Bonkowski, Michael S.; Spong, Adam; Bartke, Andrzej; Pawlikowska, Ludmila; Kwok, Pui-Yan; Masternak, Michal M.
- Abstract
Growth hormone receptor knockout (GHRKO) mice live about 40%–55% longer than their normal (N) littermates. Previous studies of 21-month-old GHRKO and N mice showed major alterations of the hepatic expression of genes involved in insulin signaling. Differences detected at this age may have been caused by the knockout of the growth hormone receptor (GHR) or by differences in biological age between GHRKO and N mice. To address this question, we compared GHRKO and N mice at ages corresponding to the same percentage of median life span to see if the differences of gene expression persisted. Comparison of GHRKO and N mice at ∼50% of biological life span showed significant differences in hepatic expression of all 14 analyzed genes. We conclude that these changes are due to disruption of GHR gene and the consequent suppression of growth hormone signaling rather than to differences in “biological age” between mutant and normal animals sampled at the same chronological age.
- Subjects
SOMATOTROPIN; HORMONE receptors; AGING; INSULIN; MEDICAL research; GENE expression
- Publication
Journals of Gerontology Series A: Biological Sciences & Medical Sciences, 2009, Vol 64A, Issue 11, p1126
- ISSN
1079-5006
- Publication type
Article
- DOI
10.1093/gerona/glp111