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- Title
Alterations in intra- and internetwork functional connectivity associated with levetiracetam treatment in temporal lobe epilepsy.
- Authors
Pang, Xiao-Min; Liang, Xiu-Lin; Zhou, Xia; Liu, Jin-Ping; Zhang, Zhao; Zheng, Jin-Ou
- Abstract
Objective: Levetiracetam (LEV) is an antiepileptic drug with a novel pharmacological mechanism. Advances in functional magnetic resonance imaging (fMRI) enable researchers to explore the cognitive effects of antiepileptic drugs on the living brain. This study aimed to explore how the functional connectivity patterns of the cognitive networks changed in association with LEV treatment. Methods: Patients with temporal lobe epilepsy (TLE), including both users and nonusers of LEV, were included in this study along with healthy controls. Core cognitive networks were extracted using an independent component analysis approach. Functional connectivity patterns within and between networks were investigated. The relationships between functional connectivity patterns and clinical characteristics were also examined. Results: The patterns of intranetwork connectivity in the default mode network (DMN), left executive control network (lECN), and dorsal attention network (DAN) differed among the three groups. The internetwork interactions did not show intergroup differences once corrected for multiple comparisons. No correlation between functional connectivity and clinical characteristics was found in patients with TLE. Conclusions: Changes in intranetwork connectivity are a key effect of LEV administration. Significance: Alterations in intranetwork connectivity patterns may underlie the cognitive effects of LEV administration; this finding improves our understanding of the neural mechanisms of LEV therapy.
- Subjects
FUNCTIONAL connectivity; TEMPORAL lobe epilepsy; FUNCTIONAL magnetic resonance imaging; INDEPENDENT component analysis; LEVETIRACETAM
- Publication
Neurological Sciences, 2020, Vol 41, Issue 8, p2165
- ISSN
1590-1874
- Publication type
Article
- DOI
10.1007/s10072-020-04322-8