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- Title
Malignant melanoma of the leg – challenges. A case report.
- Authors
Moraru, Mihaela; Goga, Iolanda; Ilie, Maria-Andreea; Stănculeanu, Dana-Lucia; Gheorghe, Adelina-Silvana; Dumitrescu, Elena-Adriana; Zob, Daniela-Luminiţa
- Abstract
Cutaneous malignant melanoma is the 15th most common cancer among women, and the incidence and mortality associated with malignant melanoma continue to increase. There are several histopathological subtypes: superficial spreading, nodular, lentigo maligna, acral lentiginous, desmoplastic, and amelanotic. In this case report, we present the histopathological, local and therapeutic evolution of this aggressive pathology. A young female patient was initially diagnosed with nodular cutaneous melanoma at the lower one-third of the calf in an advanced stage, necessitating limb amputation. However, the treatment began with systemic therapy using checkpoint inhibitors as the initial therapeutic stage. Subsequently, due to resistance to this therapy and the development of an immune-related adverse reaction, targeted therapy with BRAF/MEK inhibitors was initiated, the patient presenting the positive BRAF mutation. Thus, a favorable response was achieved through the durable effects of immunotherapy and treatment with BRAF/MEK inhibitors, leading to the conversion of the lesion to a state amenable to limited resection.
- Subjects
CUTANEOUS malignant melanoma; MELANOMA; BRAF genes; CANCER patients
- Publication
Oncolog-Hematolog, 2024, Issue 66, p12
- ISSN
2066-8716
- Publication type
Article