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- Title
HFS-14, a Specific Quality of Life Scale Developed for Patients Suffering from Hand-Foot Syndrome.
- Authors
Sibaud, Vincent; Dalenc, Florence; Chevreau, Christine; Roch, Henri; Delord, Jean-Pierre; Mourey, Loc; Lacaze, Jean-Louis; Rahhali, Nora; Taeb, Charles
- Abstract
Background. Hand-foot syndrome (HFS) is a common reaction to certain chemotherapies and new iargeted therapies, impairing patient quality of life (QoL). However, there is currently no specific tool to measure QoL in patients with HFS. Objective. The objective was to develop and validate a HFS-specific QoL questionnaire (HFS-14). Patients and Methods. From a list of 31 items identified from a literature review and patient interview notes, item reduction and pilot testing by cognitive debriefing resulted in a final 14-item questionnaire with excellent internal reliability. Clinical validity was assessed in 43 patients with HFS by comparing the HFS-14 score according to HFS clinical grade based on the National Cancer Institute Common Terminology Criteria for Adverse Events (NCICTCAE), version 3.0, and by measuring its correlation with the Dermatology Life Quality Index (DLQI), Skindex- 16, and short-form 12 health-related questionnaires and pain measurement. Results. The mean HFS-14 score was significantly higher in patients with clinical grade 2 and grade 3 HFS than in those with grade 1 HFS. The higher the HFS-14 score, the greater the QoL impairment. The HFS-14 score was highly correlated with the DLQI and Skindex-16 scores. In the population of patients with severe grade 3 NCI-CTCAE HFS, the HFS-14 score was significantly higher in patients having both hands and feet severely involved than in those with severe involvement of one limb (hands or feet) with the other one less severely affected. Conclusions. This scale specifically developed for patients with HFS is a valid and valuable tool for measuring HFS-related QoL impairment.
- Subjects
FRANCE; QUALITY of life; QUESTIONNAIRES; STATISTICAL correlation; EXPERIMENTAL design; FOOT diseases; HAND; INTERVIEWING; RESEARCH methodology; RESEARCH evaluation; TRANSLATIONS; PAIN measurement; VISUAL analog scale; CROSS-sectional method; RESEARCH methodology evaluation; DATA analysis software; DESCRIPTIVE statistics
- Publication
Oncologist, 2011, Vol 16, Issue 10, p1469
- ISSN
1083-7159
- Publication type
Article
- DOI
10.1634/theoncologist.2011-0033