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- Title
Genetic Aspects of Familial Thyroid Cancer.
- Authors
MORRISON, PATRICK J.; ATKINSON, A. BREW
- Abstract
Familial thyroid cancer is rare, accounting for <10% of thyroid cancer cases. Activating germline point mutations in the RET proto-oncogene are associated with multiple endocrine neoplasia types 2A, 2B, and familial medullary thyroid cancer (FMTC)--around 3% of thyroid cancer cases. Familial papillary thyroid cancer (PTC) and follicular thyroid cancer (FTC) have been identified as a distinct group of familial thyroid cancers. Sporadic nonmedullary thyroid cancer (NMTC) accounts for ~90% of all thyroid cancers--about 6% of NMTCs are familial (FNMTC). Although multiple endocrine neoplasia types 2A and 2B and FMTC are well characterized, very little is known about the genetic predisposition to PTC and FTC. In this paper, the genetic types of FMTC and FNMTC are reviewed and the clinical features and screening are outlined.
- Subjects
CANCER genetics; FAMILIAL diseases; THYROID cancer; PROTO-oncogenes; CANCER diagnosis
- Publication
Oncologist, 2009, Vol 14, Issue 6, p571
- ISSN
1083-7159
- Publication type
Article
- DOI
10.1634/theoncologist.2009-0046