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- Title
The Evolution and Ecology of Oxidative and Antioxidant Status: A Comparative Approach in African Mole-Rats.
- Authors
Jacobs, Paul. J.; Hart, Daniel W.; Merchant, Hana N.; Voigt, Cornelia; Bennett, Nigel C.
- Abstract
The naked mole-rat of the family Bathyergidae has been the showpiece for ageing research as they contradict the traditional understanding of the oxidative stress theory of ageing. Some other bathyergids also possess increased lifespans, but there has been a remarkable lack of comparison between species within the family Bathyergidae. This study set out to investigate how plasma oxidative markers (total oxidant status (TOS), total antioxidant capacity (TAC), and the oxidative stress index (OSI)) differ between five species and three subspecies of bathyergids, differing in their maximum lifespan potential (MLSP), resting metabolic rate, aridity index (AI), and sociality. We also investigated how oxidative markers may differ between captive and wild-caught mole-rats. Our results reveal that increased TOS, TAC, and OSI are associated with increased MLSP. This pattern is more prevalent in the social-living species than the solitary-living species. We also found that oxidative variables decreased with an increasing AI and that wild-caught individuals typically have higher antioxidants. We speculate that the correlation between higher oxidative markers and MLSP is due to the hypoxia-tolerance of the mole-rats investigated. Hormesis (the biphasic response to oxidative stress promoting protection) is a likely mechanism behind the increased oxidative markers observed and promotes longevity in some members of the Bathyergidae family.
- Subjects
OXIDANT status; COMPARATIVE method; NAKED mole rat; OXIDATIVE stress
- Publication
Antioxidants, 2023, Vol 12, Issue 8, p1486
- ISSN
2076-3921
- Publication type
Article
- DOI
10.3390/antiox12081486