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- Title
Flavonoid-Conjugated Gadolinium Complexes as Anti-Inflammatory Theranostic Agents.
- Authors
Yang, Byeong Woo; Yang, Sohyeon; Kim, Soyeon; Baek, Ah Rum; Sung, Bokyung; Kim, Yeoun-Hee; Lee, Jung Tae; Lee, Sang Yun; Kim, Hee-Kyung; Choi, Garam; Park, Ji-Ae; Nam, Sung-Wook; Lee, Gang-Ho; Chang, Yongmin
- Abstract
In this study, we designed, synthesized, and evaluated gadolinium compounds conjugated with flavonoids as potential theranostic agents for the treatment of inflammation. These novel theranostic agents combine a molecular imaging agent and one of three flavonoids (galangin, chrysin, and 7-hydroxyflavone) as anti-inflammatory drugs as a single integrated platform. Using these agents, MR imaging showed contrast enhancement (>10 in CNR) at inflamed sites in an animal inflammation model, and subsequent MR imaging used to monitor the therapeutic efficacy of these integrated agents revealed changes in inflamed regions. The anti-inflammatory effects of these agents were demonstrated both in vitro and in vivo. Furthermore, the antioxidant efficacy of the agents was evaluated by measuring their reactive oxygen species scavenging properties. For example, Gd-galangin at 30 μM showed a three-fold higher ROS scavenging of DPPH. Taken together, our findings provide convincing evidence to indicate that flavonoid-conjugated gadolinium compounds can be used as potentially efficient theranostic agents for the treatment of inflammation.
- Subjects
ANTI-inflammatory agents; GADOLINIUM; GADOLINIUM compounds; ANIMAL models of inflammation; MAGNETIC resonance imaging; REACTIVE oxygen species
- Publication
Antioxidants, 2022, Vol 11, Issue 12, p2470
- ISSN
2076-3921
- Publication type
Article
- DOI
10.3390/antiox11122470