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- Title
Lobe-specific Lymph Node Dissection in Clinical Stage IA Solid-dominant Non-small-cell Lung Cancer: A Propensity Score Matching Study.
- Authors
Zhao, Yue; Mao, Yousheng; He, Jie; Gao, Shugeng; Zhang, Zhirong; Ding, Ningning; Xue, Qi; Gao, Yushun; Wang, Dali; Zhao, Jun; Tan, Fengwei; Yuan, Ligong; Li, Feng; Wang, Shuaibo; Yang, Lin
- Abstract
<bold>Background: </bold>Lobectomy with systematic lymph node dissection (SND) remains the standard procedure for resectable non-small-cell lung cancer (NSCLC), whereas lobe-specific lymph node dissection (LSND) was reported to have more advantages in perioperative recovery and complication reduction in treating early-stage diseases. Survival outcomes after LSND remains controversial compared with SND.<bold>Patients and Methods: </bold>From 2014 to 2017, data of 546 patients with clinical stage IA solid-dominant NSCLC and who underwent curative lobectomies with LSND (n = 100) or SND (n = 446) at our institution were collected. Propensity score matching was conducted to eliminate the biases. Five-year disease-free survival and overall survival were compared between the groups. Perioperative parameters and postoperative complications were also analyzed.<bold>Results: </bold>Lobectomies with LSND or SND were performed in 100 patients and 446 patients, respectively. After matching, there were 100 patients in each group and no significant differences in 5-year overall survival (P = .473) and disease-free survival (P = .789) were found between the groups. Recurrence patterns were also similar (P = .733). Perioperative parameters were similar, whereas the incidence of postoperative complications in the SND group was found to be significantly higher than that in the LSND group (P = .003).<bold>Conclusions: </bold>Our study demonstrated that LSND has similar efficiency to SND in terms of survival, recurrence, lymph node dissection, and perioperative recovery of patients with clinical stage IA solid-dominant NSCLC, as well as significant advantages in reducing postoperative complications. Therefore, curative lobectomies with LSND may be more suitable and practical for clinical stage IA solid-dominant patients with NSCLC.
- Subjects
LUNG cancer; SURVIVAL; RESEARCH; ENDOSCOPIC surgery; RESEARCH methodology; LUNG tumors; PROGNOSIS; METASTASIS; SURGICAL complications; MEDICAL cooperation; EVALUATION research; TUMOR classification; DISEASE relapse; COMPARATIVE studies; SURGICAL excision; LYMPH node surgery; PROBABILITY theory; PNEUMONECTOMY; LONGITUDINAL method
- Publication
Clinical Lung Cancer, 2021, Vol 22, Issue 2, pe201
- ISSN
1525-7304
- Publication type
journal article
- DOI
10.1016/j.cllc.2020.09.012