We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Risperidone reverses the spatial object recognition impairment and hippocampal BDNF-TrkB signalling system alterations induced by acute MK-801 treatment.
- Authors
GUANGDONG CHEN; XIAODONG LIN; GONGYING LI; DIEGO JIANG; ZHIRUO LIB; RONGHUAN JIANG; CHUANJUN ZHUO
- Abstract
The aim of the present study was to investigate the effects of a commonly-used atypical antipsychotic, risperidone, on alterations in spatial learning and in the hippocampal brain-derived neurotrophic factor (BDNF)-tyrosine receptor kinase B (TrkB) signalling system caused by acute dizocilpine maleate (MK-801) treatment. In experiment 1, adult male Sprague-Dawley rats subjected to acute treatment of either low-dose MK801 (0.1 mg/kg) or normal saline (vehicle) were tested for spatial object recognition and hippocampal expression levels of BDNF, TrkB and the phophorylation of TrkB (p-TrkB). We found that compared to the vehicle, MK-801 treatment impaired spatial object recognition of animals and downregulated the expression levels of p-TrkB. In experiment 2, MK-801- or vehicle-treated animals were further injected with risperidone (0.1 mg/kg) or vehicle before behavioural testing and sacrifice. Of note, we found that risperidone successfully reversed the deleterious effects of MK-801 on spatial object recognition and upregulated the hippocampal BDNF-TrkB signalling system. Collectively, the findings suggest that cognitive deficits from acute N-methyl-D-aspartate receptor blockade may be associated with the hypofunction of hippocampal BDNF-TrkB signalling system and that risperidone was able to reverse these alterations.
- Subjects
ANTIPSYCHOTIC agents; BRAIN-derived neurotrophic factor; TYROSINE; DIZOCILPINE; PHOSPHORYLATION
- Publication
Biomedical Reports, 2017, Vol 6, Issue 3, p285
- ISSN
2049-9434
- Publication type
Article
- DOI
10.3892/br.2017.850