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- Title
Primary mucosa-associated lymphoid tissue lymphoma of the prostate: Tumor relapse 7 years after local therapy.
- Authors
Li, Chunmei; Hibino, Mitsunobu; Komatsu, Hirokazu; Sakuma, Hidenori; Sakakura, Takeshi; Ueda, Ryuzo; Eimoto, Tadaaki; Inagaki, Hiroshi
- Abstract
Primary mucosa-associated lymphoid tissue (MALT) lymphoma of the prostate is rare, and only five cases have been reported. Reported herein is a new case that has involved a 9 year follow up. A 79-year-old man was treated with transurethral resection (TUR) for a mass of the right prostatic lobe, and followed up under a diagnosis of benign prostatic hyperplasia with atypical lymphoid infiltration. Seven years later TUR was again performed for a right lobe mass. The lesion was diagnosed as a relapsed MALT lymphoma after detailed histological and immunoglobulin heavy chain gene analyses of the initial and relapsed lesions. Interestingly, lymphoepithelial lesions were observed only infrequently in this tumor. The API2-MALT1 fusion, a gene alteration specific to MALT lymphoma, was absent. The patient had stage IA disease at the time of tumor relapse, and has been alive and well for the 2 years after the second TUR. The present case suggests that despite tumor recurrence, prostatic MALT lymphoma is indolent, and function-preserving therapy is warranted.
- Subjects
MUCOSA-associated lymphoid tissue lymphoma; LYMPHOMAS; PROSTATE hypertrophy; TUMORS; CANCER relapse; IMMUNOGLOBULINS
- Publication
Pathology International, 2008, Vol 58, Issue 3, p191
- ISSN
1320-5463
- Publication type
Article
- DOI
10.1111/j.1440-1827.2007.02210.x