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- Title
Electrostatic Repulsion-Hydrophilic Interaction Chromatography: Using One Mode to Tune Retention from a Second Mode.
- Authors
Alpert, Andrew; Heckendorf, Amos
- Abstract
When electrostatic effects are superimposed on hydrophilic interactions, specific functional groups can be selected (when the column has the opposite charge) or de-selected (when the column has the same charge). This can be exploited to isolate compounds, such as phosphopeptides, or to diminish the role of basic groups in solutes to enhance the selectivity for the rest of the molecule.
- Subjects
ELECTROSTATICS; ELECTROSTATIC atomization; ELECTRIC discharges; ELECTRIC charge; ELECTROSTATIC adhesion; REPULSION-induction electric motors; PHOSPHORUS compounds
- Publication
LC-GC Europe, 2011, Vol 24, Issue 1, p10
- ISSN
1471-6577
- Publication type
Article