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- Title
Validation of genome-wide associated variants for Kawasaki disease in a Taiwanese case–control sample.
- Authors
Chen, Ming-Ren; Chang, Tzu-Yang; Chiu, Nan-Chang; Chi, Hsin; Yang, Kuender D.; Chang, Lung; Huang, Daniel Tsung-Ning; Huang, Fu-Yuan; Lien, Ya-Ping; Lin, Wen-Shan; Lin, Chiung-Ling; Chang, Luan-Yin; Lee, Yann-Jinn
- Abstract
Kawasaki disease (KD) is an acute febrile systemic vasculitis of unknown etiology that affects infants and young children. Considerable evidence supports the hypothesis that there is a genetic basis for KD susceptibility. Genome-wide association studies (GWAS) have identified several genetic variants associated with KD. This study aims to replicate three novel KD-associated single nucleotide polymorphisms (SNPs), identified by GWAS in Japanese, in a Taiwanese population. Associations between these SNPs and development of coronary artery lesions (CALs) were also investigated. The rs2254546 A/G, rs2857151 A/G, and rs4813003 C/T SNPs were genotyped in 681 children with KD and 563 ethnically-matched healthy controls using TaqMan Assay or DNA sequencing. We found rs2254546 and rs4813003 SNPs were significantly associated with KD (G allele, odds ratio [OR] = 1.54, P = 1.0 × 10–5; C allele, OR = 1.32, P = 8.1 × 10–4). However, no evidence for associations with CAL development was observed. Our study successfully validates associations of the rs2254546 and rs4813003 SNPs with KD in a Taiwanese population. Further functional studies of the SNPs are important in understanding the pathogenesis of KD.
- Subjects
MUCOCUTANEOUS lymph node syndrome; TAIWANESE people; SINGLE nucleotide polymorphisms; NUCLEOTIDE sequencing; GENOTYPES
- Publication
Scientific Reports, 2020, Vol 10, Issue 1, p1
- ISSN
2045-2322
- Publication type
Article
- DOI
10.1038/s41598-020-68673-0