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- Title
PD-L1 Expression Is an Independent Marker for Lymph Node Metastasis in Middle Eastern Endometrial Cancer.
- Authors
Siraj, Abdul K.; Parvathareddy, Sandeep Kumar; Annaiyappanaidu, Padmanaban; Siraj, Nabil; Al-Rasheed, Maha; Al-Badawi, Ismail A.; Al-Dayel, Fouad; Al-Kuraya, Khawla S.; Ragazzi, Moira; de Biase, Dario
- Abstract
Programmed death ligand 1 (PD-L1) expression in endometrial cancer (EC) tumor cells have been reported in several studies with inconsistent results. Furthermore, there is scarcity of data on the prevalence and prognostic significance of PD-L1 expression in EC from Middle Eastern ethnicity. We aimed to assess PD-L1 expression in a large cohort of Middle Eastern EC and to correlate this with clinico-pathological factors, as well as mismatch repair (MMR) protein status and patients' outcome. PD-L1 expression was investigated using immunohistochemistry on tissue microarray in an unselected cohort of 440 EC. Kaplan–Meier and logistic regression analysis were used to compare the outcome and prognostic factors. PD-L1 expression in tumor tissue was detected in 18.9% (83/440) EC cases with no impact on survival. When stratified for MMR protein status, PD-L1 expression was similar for both MMR deficient and MMR proficient ECs. However, the expression of PD-L1 in tumor cells was significantly associated with type II (non-endometrioid) histology (p = 0.0005) and lymph node metastasis (p = 0.0172). Multivariate analysis showed PD-L1 expression to be an independent risk factor for lymph node metastasis (odds ratio: 2.94; 95% CI: 1.26–6.84; p = 0.0123). In conclusion, PD-L1 was strongly associated with non-endometrioid EC and was an independent prognostic marker of lymph node metastasis.
- Subjects
LYMPHATIC metastasis; ENDOMETRIAL tumors; ENDOMETRIAL cancer; PROGRAMMED death-ligand 1; LOGISTIC regression analysis; PROGNOSIS
- Publication
Diagnostics (2075-4418), 2021, Vol 11, Issue 3, p394
- ISSN
2075-4418
- Publication type
Article
- DOI
10.3390/diagnostics11030394