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- Title
Imaging of Adverse Events Related to Checkpoint Inhibitor Therapy.
- Authors
Vani, Vanina; Regge, Daniele; Cappello, Giovanni; Gabelloni, Michela; Neri, Emanuele
- Abstract
Immunotherapy with checkpoint inhibitors (ICIs) is becoming standard of practice for an increasing number of cancer types. ICIs enhance T-cell action against the cancer cells. By unbalancing the immune system ICIs may cause dysimmune toxicities, a series of disorders broadly defined immune-related adverse events (irAEs). IrAEs may affect any organ or apparatus and most frequently involve skin, colon, endocrine organs, liver, and lungs. Early identification and appropriate treatment of irAEs can improve patient outcome. The paper aims at reviewing mechanisms of the occurrence of irAEs, the importance of a proper diagnosis and the main pillars of therapy. To provide effective guidance to the comprehension of major irAEs imaging findings will be reviewed.
- Subjects
ADVERSE health care events; IMMUNE checkpoint inhibitors; COLON (Anatomy); IMMUNE system; CANCER cells
- Publication
Diagnostics (2075-4418), 2020, Vol 10, Issue 4, p216
- ISSN
2075-4418
- Publication type
Article
- DOI
10.3390/diagnostics10040216