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- Title
Heteromer Nanostars by Spontaneous Self-Assembly.
- Authors
Brocker, Caitlin; Kim, Hannah; Smith, Daniel; Barua, Sutapa
- Abstract
Heteromer star-shaped nanoparticles have the potential to carry out therapeutic agents, improve intracellular uptake, and safely release drugs after prolonged periods of residence at the diseased site. A one-step seed mediation process was employed using polylactide-co-glycolic acid (PLGA), polyvinyl alcohol (PVA), silver nitrate, and tetrakis(hydroxymethyl)phosphonium chloride (THPC). Mixing these reagents followed by UV irradiation successfully produced heteromer nanostars containing a number of arm chains attached to a single core with a high yield. The release of THPC from heteromer nanostars was tested for its potential use for breast cancer treatment. The nanostars present a unique geometrical design exhibiting a significant intracellular uptake by breast cancer cells but low cytotoxicity that potentiates its efficacy as drug carriers.
- Subjects
NANOPARTICLES; POLYLACTIC acid; BREAST cancer treatment; THERAPEUTICS
- Publication
Nanomaterials (2079-4991), 2017, Vol 7, Issue 6, p127
- ISSN
2079-4991
- Publication type
Article
- DOI
10.3390/nano7060127