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- Title
Mild hyperhomocysteinaemia is associated with increased aortic stiffness in general population.
- Authors
Mayer Jr, O.; Filipovský, J.; Dolejšová, M.; Cífková, R.; Šimon, J.; Bolek, L.
- Abstract
Total homocysteine (tHcy) level was identified as a strong and independent predictor of cardiovascular events. We investigated the association between tHcy and mechanical properties of large arteries in a random, general population-based sample of 251 subjects (mean age 48 years). Large artery properties, such as aortic and peripheral (lower-limb) pulse wave velocity (PWV), and augmentation index of radial artery were measured using semi-automatic Sphygmocor® device. Aortic PWV (APWV) positively correlated with tHcy (r=0.28, P<0.0001), and a significant increasing trend of APWV was found by tHcy quartiles (P=0.0003 by ANOVA). This association remained significant after adjustment for conventional cardiovascular risk factors (age, gender, smoking, overweight, hypertension, dyslipidaemia and impaired glucose metabolism) and for usual homocysteine confounders (folate, B12, renal function). Subjects with mild hyperhomocysteinaemia (i.e. with tHcy 15 μmol/l) had 2.74 times higher risk of having their APWV over 8.42 m/s (i.e. in the top quartile). No such association was found either for PWV measured at lower extremity or for radial augmentation index. In conclusion, in our series of subjects from general population, we found a strong and independent relationship between homocysteine concentration and APWV, a parameter of stiffness of central arteries.Journal of Human Hypertension (2006) 20, 267–271. doi:10.1038/sj.jhh.1001983; published online 26 January 2006
- Subjects
CARDIOVASCULAR diseases; DISEASE risk factors; HOMOCYSTEINE; SULFUR amino acids; HYPERTENSION; BLOOD circulation disorders
- Publication
Journal of Human Hypertension, 2006, Vol 20, Issue 4, p267
- ISSN
0950-9240
- Publication type
Article
- DOI
10.1038/sj.jhh.1001983