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- Title
The controversial role of serum uric acid in essential hypertension: relationships with indices of target organ damage.
- Authors
Tsioufis, C.; Chatzis, D.; Vezali, E.; Dimitriadis, K.; Antoniadis, D.; Zervoudaki, A.; Lalos, S.; Kallikazaros, I.; Stefanadis, C.; Toutouzas, P.
- Abstract
The role of serum uric acid (SUA) in the context of adverse cardiovascular events in hypertensive subjects is controversial. Additionally, the relationship between SUA and indices of target organ damage is not well defined in this setting. Towards this end, we studied 842 consecutive nondiabetic patients with stage I-II essential hypertension (office blood pressure=148/95?mmHg, aged 53.4 years), referred to our outpatient hypertensive unit within a period of 4 years. According to the urinary albumin excretion (UAE), the study population was classified into those with microalbuminuria[MA(+), UAE=20-200?mg/24?h, n=222]and those without MA[MA (-), UAE<20?mg/24?h, n=620]. Moreover, according to the presence of left ventricular hypertrophy (LVH) the participants were subdivided into two additional groups:[LVH (+), n=305 and LVH (-), n=537]. SUA levels were higher by 0.4?mg/dl, (P=0.04) in group MA (+) compared with the group MA (-), while no difference was observed between groups LVH (+) and LVH (-) (P=NS). In the entire population, SUA was correlated with body mass index (BMI) (r=0.17, P<0.001), waist/hip ratio (r=0.3, P<0.001), office systolic blood pressure (SBP) (r=0.14, P<0.05), triglycerides levels (r=0.25, P<0.001), UAE (r=0.35, P<0.001) and HDL (r=-0.26, P<0.001). Multiple regression analysis demonstrated that SUA was significantly related with BMI, office SBP and UAE (P<0.05). In conclusion, increased SUA levels are associated with MA but not with LVH in essential hypertensive subjects. Whether these inter-relationships may elucidate the clinical positioning of augmented SUA in this setting remains to be clarified in future studies.Journal of Human Hypertension (2005) 19, 211-217. doi:10.1038/sj.jhh.1001810 Published online 13 January 2005
- Subjects
URIC acid; HYPERTENSION; HYPERURICEMIA; ALBUMINURIA; CARDIOVASCULAR diseases; TARGET organs (Anatomy)
- Publication
Journal of Human Hypertension, 2005, Vol 19, Issue 3, p211
- ISSN
0950-9240
- Publication type
Article
- DOI
10.1038/sj.jhh.1001810