We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Comment on: Evaluation of the Influence of Sildenafil on the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Vericiguat in Healthy Adults.
- Authors
Ganijee, Mustafa; Sahgal, Gaayen Ravii; Latif, Bilal; Ahmad, Malik Takreem
- Abstract
Therefore, further investigation of the safety profile in the broader population is required, as the vericiguat + sildenafil group reported 100% more TEAEs than the placebo + sildenafil group (43.8%). Lastly, while the study concluded that neither drug had a clinically meaningful impact on the other's pharmacokinetics, this perspective may be too narrow, considering the potential for patients to be receiving multiple medications. This single-centre, randomised, placebo-controlled study adds to our knowledge of taking these combined medications, and given the increasing instances of their concurrent usage in heart failure patients with erectile dysfunction, this area of research is fast becoming one of interest.
- Subjects
ADULTS; SILDENAFIL; PHARMACOKINETICS; PHARMACODYNAMICS; IMPOTENCE
- Publication
Clinical Pharmacokinetics, 2023, Vol 62, Issue 11, p1649
- ISSN
0312-5963
- Publication type
Article
- DOI
10.1007/s40262-023-01303-w