We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Therapeutic Effect of Yoga in Patients with Hypertension with Reference to GST Gene Polymorphism.
- Authors
Dhameja, Kanupriya; Singh, Savita; Mustafa, M. D.; Singh, K. P.; Banerjee, Basu Dev; Agarwal, Mukul; Ahmed, Rafat S.
- Abstract
Background: Hypertension, a chronic medical condition of increased blood pressure, is a serious public health problem. Environmental and genetic risk factors are known to predispose to hypertension. The present study was designed to investigate the association of glutathione S-transferase ( GST) gene polymorphism with oxidative stress in hypertensive patients and the possible beneficial effect of yoga on them. Materials and methods: Sixty (60) hypertensive individuals, between 30 and 60 years of age, were divided into two groups of 30 each. The yoga group was subjected to 50-60 minutes of yogic practices daily for 42 days, while the control group included the remaining 30 age- and sex-matched hypertensive individuals. GST gene polymorphism was analyzed using multiple allele specific polymerase chain reaction, and oxidative stress parameters were assessed biochemically. Results: Assessment of blood pressure showed a statistically significant though modest reduction ( p<0.05) in the yoga group as compared to the control group. Malondialdehyde was observed to be significantly low ( p<0.05), while antioxidant capacity in the form of GST showed an increasing trend and ferric-reducing ability of plasma was significantly increased ( p<0.05) in the subjects who practiced yoga. Conclusions: In conclusion, yoga has been found to decrease blood pressure as well as the levels of oxidative stress in patients with hypertension.
- Subjects
INDIA; THERAPEUTICS; HYPERTENSION; EXERCISE therapy; ALLELES; ANTHROPOMETRY; BLOOD pressure measurement; ELECTROPHORESIS; ENZYMES; EXERCISE physiology; GENES; GENETIC polymorphisms; GLUTATHIONE; LIPID peroxidation (Biology); POLYMERASE chain reaction; STATISTICAL hypothesis testing; T-test (Statistics); YOGA; OXIDATIVE stress; BODY mass index; DESCRIPTIVE statistics
- Publication
Journal of Alternative & Complementary Medicine, 2013, Vol 19, Issue 3, p243
- ISSN
1075-5535
- Publication type
Journal Article
- DOI
10.1089/acm.2011.0908