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- Title
HAX1 deficiency: Impact on lymphopoiesis and B-cell development.
- Authors
Peckl-Schmid, Doris; Wolkerstorfer, Susanne; Königsberger, Sebastian; Achatz-Straussberger, Gertrude; Feichtner, Stefan; Schwaiger, Elisabeth; Zaborsky, Nadja; Huemer, Michael; Gratz, Iris K.; Schibli, Roger; Lamers, Marinus; Crameri, Reto; Moser, Katrin; Luger, Elke O; Achatz, Gernot
- Abstract
HAX1 was originally described as HS1-associated protein with a suggested function in receptor-mediated apoptotic and proliferative responses of lymphoid cells. Recent publications refer to a complex and multifunctional role of this protein. To investigate the in vivo function of HAX1 (HS1-associated protein X1) in B cells, we generated a Hax1-deficient mouse strain. Targeted deletion of Hax1 resulted in premature death around the age of 12 wk accompanied by a severe reduction of lymphocytes in spleen, thymus and bone marrow. In the bone marrow, all B-cell populations were lost comparably. In the spleen, B220
- Publication
European Journal of Immunology, 2010, Vol 40, Issue 11, p3161
- ISSN
0014-2980
- Publication type
Article
- DOI
10.1002/eji.200940221