We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Distinct Role of Striatal Functional Connectivity and Dopaminergic Loss in Parkinson's Symptoms.
- Authors
Dukart, Juergen; Sambataro, Fabio; Bertolino, Alessandro
- Abstract
Degeneration of dopaminergic neurons is a hallmark of Parkinson's disease. However, its link to Parkinson's disease symptoms remains unclear. Striatal resting state functional connectivity differentiates between Parkinson's disease patients and healthy controls and might be a potential mediator of the effects of striatal dopaminergic degeneration onto Parkinson's disease symptoms. Here, we evaluated the relationship between dopaminergic deficits, striatal functional connectivity (SFC) at rest and different Parkinson's disease clinical symptoms in the largest currently established cohort of de novo Parkinson's disease patients. We show that SFC is an independent predictor of symptom severity in Parkinson's disease in addition to striatal dopaminergic deficits. Furthermore, we find that distinct SFC networks are associated with symptoms reflecting the ability to perform daily routine automatized motor tasks and clinicianrated Parkinson's disease motor symptoms. We find that reduced SFC is a major and independent predictor of Parkinson's disease symptoms going beyond the mere reflection of striatal dopaminergic input loss. These findings indicate the high value of SFC as a clinically relevant biomarker in Parkinson's disease.
- Subjects
BRAIN function localization; DOPAMINERGIC neurons; PARKINSON'S disease; SYMPTOMS; TASK performance; COHORT analysis
- Publication
Frontiers in Aging Neuroscience, 2017, p1
- ISSN
1663-4365
- Publication type
Article
- DOI
10.3389/fnagi.2017.00151