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- Title
Epstein-Barr Virus Association with Peptic Ulcer Disease.
- Authors
Cárdenas-Mondragón, María G.; Torres, Javier; Carreón-Talavera, Ricardo; Camorlinga-Ponce, Margarita; Flores-Luna, Lourdes; Fuentes-Pananá, Ezequiel M.
- Abstract
Background. Helicobacter pylori (HP) infection and nonsteroidal anti-inflammatory drugs (NSAID) use are considered the main risk to develop peptic ulcer disease (PUD). However, PUD also occurs in the absence of HP infection and/or NSAID use. Recently, we have found evidence that Epstein-Barr virus (EBV) reactivation increases the risk to develop premalignant and malignant gastric lesions. Objective. To study a possible association between EBV and PUD. Methods. Antibodies against an EBV reactivation antigen, HP, and the HP virulence factor CagA were measured in sera from 207 Mexican subjects, controls (healthy individuals, n = 129), and PUD patients (n = 78, 58 duodenal and 20 gastric ulcers). Statistical associations were estimated. Results. Duodenal PUD was significantly associated with high anti-EBV IgG titers (p = 0.022, OR = 2.5), while anti-EBV IgA was positively associated with gastric PUD (p = 0.002, OR = 10.1). Conclusions. Our study suggests that EBV reactivation in gastric and duodenal epithelium increases the risk to develop PUD.
- Subjects
EPSTEIN-Barr virus diseases; PEPTIC ulcer; HELICOBACTER pylori; NONSTEROIDAL anti-inflammatory agents; MEXICANS; HEALTH
- Publication
Analytical Cellular Pathology: Cellular Oncology, 2015, Vol 2015, p1
- ISSN
2210-7177
- Publication type
Article
- DOI
10.1155/2015/164840