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- Title
Effects of bariatric surgery on pericardial ectopic fat depositions and cardiovascular function.
- Authors
Schinkel, Linda D.; Sleddering, Maria A.; Lips, Mirjam A.; Jonker, Jacqueline T.; Roos, Albert; Lamb, Hildo J.; Jazet, Ingrid M.; Pijl, Hanno; Smit, Johannes W. A.
- Abstract
Objective Cardiac ectopic fat depositions are thought to play a role in the pathogenesis of cardiovascular disease ( CVD), the main cause of death in patients with type 2 diabetes. Diet-induced weight loss results in a decrease in cardiac ectopic fat stores, however if this is the same for surgically induced weight loss is less clear. Therefore, we assessed myocardial triglyceride ( TG) content, pericardial fat and cardiac function in obese patients with insulin-dependent type 2 diabetes before and 16 weeks after Roux-en- Y gastric bypass ( RYGB) surgery. Patients Ten obese patients with insulin-dependent type 2 diabetes [40% male, age 53·7 ± 8·9 years (mean ± SD)] scheduled to undergo RYGB surgery were included. Measurements Ectopic fat accumulation and cardiovascular function were assessed with magnetic resonance ( MR) imaging and myocardial TG content with MR spectroscopy before and 16 weeks after RYGB surgery. Results Body mass index decreased from 41·3 ± 4·3 at baseline to 34·1 ± 2·8 kg/m2 ( P < 0·001) after 16 weeks. Glycemic control improved as well [ Hb A1c: 7·8 ± 1·1 to 6·8 ± 1·3% (62 ± 12 to 51 ± 14 m m) ( P < 0·05)]. We did not observe an effect of the RYGB surgery on myocardial TG content, cardiac function or pulse wave velocity. There was a greater relative decrease in visceral (−35·5 ± 9·6%) as compared to subcutaneous fat volume (−25·0 ± 6·3%) and in paracardial (−17·3 ±17·2%) as compared to epicardial fat volume (−6·4 ± 6·0%). Conclusions This study shows that surgical-induced weight loss leads to a larger decrease in paracardial than epicardial fat. Myocardial TG and cardiovascular function did not change.
- Subjects
BARIATRIC surgery; PERICARDIAL effusion; CARDIOVASCULAR system; ECTOPIC hormones; FAT analysis; CARDIOVASCULAR disease diagnosis; WEIGHT loss; TRIGLYCERIDES
- Publication
Clinical Endocrinology, 2014, Vol 81, Issue 5, p689
- ISSN
0300-0664
- Publication type
Article
- DOI
10.1111/cen.12402