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- Title
Host-Directed Antivirals: A Realistic Alternative to Fight Zika Virus.
- Authors
Saiz, Juan-Carlos; de Oya, Nereida Jiménez; Blázquez, Ana-Belén; Escribano-Romero, Estela; Martín-Acebes, Miguel A.
- Abstract
Zika virus (ZIKV), a mosquito-borne flavivirus, was an almost neglected pathogen until its introduction in the Americas in 2015, where it has been responsible for a threat to global health, causing a great social and sanitary alarmdue to its increased virulence, rapid spread, and an associationwith severe neurological and ophthalmological complications. Currently, no specific antiviral therapy against ZIKV is available, and treatments are palliative andmainly directed toward the relief of symptoms, such as fever and rash, by administering antipyretics, anti-histamines, and fluids for dehydration. Nevertheless, lately, search for antivirals has been a major aim in ZIKV investigations. To do so, screening of libraries from different sources, testing of natural compounds, and repurposing of drugs with known antiviral activity have allowed the identification of several antiviral candidates directed to both viral (structural proteins and enzymes) and cellular elements. Here, we present an updated review of current knowledge about anti-ZIKV strategies, focusing on host-directed antivirals as a realistic alternative to combat ZIKV infection.
- Subjects
ZIKA virus; FLAVIVIRUSES; ANTIVIRAL agents; WORLD health; HISTAMINE
- Publication
Viruses (1999-4915), 2018, Vol 10, Issue 9, p453
- ISSN
1999-4915
- Publication type
Article
- DOI
10.3390/v10090453